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KMID : 0371619870030020189
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Journal of Wonkwang Medical Science
1987 Volume.3 No. 2 p.189 ~ p.200
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Ultraviolet Radiation-Exposed Animals Exhibit An Enhanced Susceptability to Bacterial and Fungal Infections
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Huh, Kee-Seok
Chung, Yun-Shin/Chung, Hun-Taeg
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Abstract
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1
UVB(280-320nm) is an environmental agent that is a large number of changes of the skin of human and animals. Now, Numerous studies on
the mechanisms affecting the immune response have been researching. But, it was not known that UVR corelated with microbial infection. Therefore, in these study, we researched to measure of recovery of various micro-organism from UV- irradiated mice that were pathogenic microorganisms. The results of this study showed that recovery of various pathogenic microorganisms in UVR-exposed mice was higher than that of in normal (non-UV irradiated) control mice. Recovery of Candida albicans, Esche - rickia soli and Siaphylococcus aureus in 3 day after UV- irradiation was highest in 0- 5 day after UV irradiation. Futher more, we studied that UVR corelated with cellular immune response. It was challenged to syngenic mice with Bacillus Calmete Guerin (BCG) and UVR was treated to the BCG- injected mice. Footpad swelling reactions were tested with.purified protein derivative (PPD) in 0-5 day after UV- irradiation. The results of these experiments exhibit that early skin reaction(4 hr after PPD treatment) is similar or reduced a little. But, delayed type hypersensitivity( 48 hr after PPD treatment) was highly reduced as compared to the control. These results suggest that UVR induce a potent immun-
´ modulation such as an altered pattern of lymphocyte recirculation, sup-pressor ´T cell induction, deviation in systemic antigen presenting cell (APC) potential, changes in the production of interleukin 1-like molecule, and the function inactivation of epidermal Langerhans cells in the process.
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KEYWORD
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